Bagnat Lab


Cellular and physiologic mechanisms controlling morphogenesis


    Our laboratory is interested in studying how basic cellular processes define the shape and size of complex multicellular structures such as organs.  Fluid movement into enclosed lumenal or intracellular spaces creates hydrostatic pressure that can serve as a driving force for organogenesis and long range morphogenetic events such as axis elongation.


    Our major focus is to study how biological tubes are assembled and to understand the role hydrostatic pressure plays as a developmental force.

Using zebrafish we investigate:

1.) Regulation of fluid secretion and the role of fluid pressure in organogenesis.

2.) The biogenesis and function of fluid-filled vacuoles in the notochord during embryogenesis and spine morphogenesis.

3.) Cellular mechanisms controlling epithelial polarization and lumen formation in the gut tube.


Contact us:


m.bagnat at

cellbio dot duke dot edu

333B Nanaline Duke Bldg.

Box 3709

Duke University Medical Center Durham, NC 27710

Telephone 919-681-9268

Fax 919-684-5481